zhongshilong 发表于 2014-6-9 23:37:35

Therapeutic drug monitoring as a component of personalized medicine (CPT)

Clin Pharmacol Ther. 2014 Feb;95(2):138-40. doi: 10.1038/clpt.2013.227. Epub 2013 Nov 19.
Therapeutic drug monitoring as a component of personalized medicine: applications in pediatric drug development.Momper JD1, Wagner JA2.
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AbstractTherapeutic drug monitoring (TDM) is foundational to the concept of personalized medicine. TDM transformeddrug therapy by affording the ability to characterize sources of variability in drug disposition and response to individualize drug dosing. Initially, TDM formed the key conceptual basis for personalized medicine, which has evolved to include pharmacogenomic and other biomarker-driven strategies for patient segmentation. Currently, TDM is an attractive option for personalized medicine and, under the right conditions, can facilitate drugdevelopment.


swhliuyao 发表于 2014-9-17 17:31:23

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